Dataset Information

High-precision multiclass cell classification by supervised machine learning on lectin microarray data.

ABSTRACT:

Introduction

Establishment of a cell classification platform for evaluation and selection of human pluripotent stem cells (hPSCs) is of great importance to assure the efficacy and safety of cell-based therapy. In our previous work, we introduced a discriminant function that evaluates pluripotency from the cells' glycome. However, it is not yet suitable for general use.

Methods

The current study aims to establish a high-precision cell classification platform introducing supervised machine learning and test the platform on glycome analysis as a proof-of-concept study. We employed linear classification and neural network to the lectin microarray data from 1577 human cells and categorized them into five classes including hPSCs.

Results

The linear-classification-based model and the neural-network-based model successfully predicted the sample type with accuracies of 89% and 97%, respectively.

Conclusions

Because of the high recognition accuracies and the small amount of computing resources required for these analyses, our platform can be a high precision conventional cell classification system for hPSCs.

SUBMITTER: Shibata M

PROVIDER: S-EPMC7770415 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

High-precision multiclass cell classification by supervised machine learning on lectin microarray data.

Shibata Mayu M Okamura Kohji K Yura Kei K Umezawa Akihiro A

Regenerative therapy 20201016

<h4>Introduction</h4>Establishment of a cell classification platform for evaluation and selection of human pluripotent stem cells (hPSCs) is of great importance to assure the efficacy and safety of cell-based therapy. In our previous work, we introduced a discriminant function that evaluates pluripotency from the cells' glycome. However, it is not yet suitable for general use.<h4>Methods</h4>The current study aims to establish a high-precision cell classification platform introducing supervised ...[more]

PMID: 33426219

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Dataset Information

High-precision multiclass cell classification by supervised machine learning on lectin microarray data.

Introduction

Methods

Results

Conclusions

Publications

High-precision multiclass cell classification by supervised machine learning on lectin microarray data.

Similar Datasets

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