Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator.

ABSTRACT:

Introduction

Considering higher risks of candidates for cardiac regenerative therapy with compromised cardiac function, it is anticipated to develop less invasive surgical procedures. In the present study, we aimed to develop a prototype of totally endoscopic cell sheet delivery device and evaluate the surgical technique for epicardial cell sheet placement using three-dimensional (3D) printed simulators based on human computed tomography data.

Methods

We designed an endoscopic cell sheet delivery device with outer and inner frame with self-expandable applicator which can be opened in thoracic cavity. We launched spout line to provide liquids on the applicator surface and tension line to gently bend the applicator dorsally. We prepared human mesenchymal stem cell (MSC) sheets

SUBMITTER: Osada H 

PROVIDER: S-EPMC7770426 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature