Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome.

ABSTRACT: Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for patients with myelodysplastic syndrome (MDS), but long-term survival is limited by the risk of transplant-related complications. Short telomere length, mediated by inherited or acquired factors, impairs cellular response to genotoxic and replicative stress and could identify patients at higher risk for toxicity after transplantation. We measured relative telomere length in pretransplant recipient blood samples in 1514 MDS patients and evaluated the association of telomere length with MDS disease characteristics and transplantation outcomes. Shorter telomere length was significantly associated with older age, male sex, somatic mutations that impair the DNA damage response, and more severe pretr

SUBMITTER: Myllymaki M 

PROVIDER: S-EPMC7770569 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature