The relative biological effectiveness of carbon ion radiation therapy for early stage lung cancer.

ABSTRACT:

Background and purpose

Carbon ion radiation therapy (CIRT) is recognized as an effective alternative treatment modality for early stage lung cancer, but a quantitative understanding of relative biological effectiveness (RBE) compared to photon therapy is lacking. In this work, a mechanistic tumor response model previously validated for lung photon radiotherapy was used to estimate the RBE of CIRT compared to photon radiotherapy, as a function of dose and the fractionation schedule.

Materials and methods

Clinical outcome data of 9 patient cohorts (394 patients) treated with CIRT for early stage lung cancer, representing all published data, were included. Fractional dose, number of fractions, treatment schedule, and local control rates were used for model simulations relative

SUBMITTER: Jeong J 

PROVIDER: S-EPMC7770609 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature