Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy.

ABSTRACT: Inconvenient dual-laser irradiation and tumor hypoxic environment as well as limited judgment of treating region have impeded the development of combined photothermal and photodynamic therapies (PTT and PDT). Herein, Bi₂Se₃@AIPH nanoparticles (NPs) are facilely developed to overcome these problems. Through a one-step method, free radical generator (AIPH) and phase transition material (lauric acid, LA, 44-46 °C) are encapsulated in hollow bismuth selenide nanoparticles (Bi₂Se₃ NPs). Under a single 808-nm laser irradiation at the tumor area, hyperthermia produced by Bi₂Se₃ not only directly leads to cell death, but also promotes AIPH release by melting LA and triggers free radical generation, which could further eradicate tumo

SUBMITTER: Li X 

PROVIDER: S-EPMC7770756 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature