Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold.

ABSTRACT: Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000-1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO₂) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO₂ nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO₂ nanostructures combined with PTT induce a synergistic antiangi

SUBMITTER: Chen JL 

PROVIDER: S-EPMC7770887 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature