Tuning Atomically Dispersed Fe Sites in Metal-Organic Frameworks Boosts Peroxidase-Like Activity for Sensitive Biosensing.

ABSTRACT: Although nanozymes have been widely developed, accurate design of highly active sites at the atomic level to mimic the electronic and geometrical structure of enzymes and the exploration of underlying mechanisms still face significant challenges. Herein, two functional groups with opposite electron modulation abilities (nitro and amino) were introduced into the metal-organic frameworks (MIL-101(Fe)) to tune the atomically dispersed metal sites and thus regulate the enzyme-like activity. Notably, the functionalization of nitro can enhance the peroxidase (POD)-like activity of MIL-101(Fe), while the amino is poles apart. Theoretical calculations demonstrate that the introduction of nitro can not only regulate the geometry of adsorbed intermediates but also improve the electronic structure of

SUBMITTER: Xu W 

PROVIDER: S-EPMC7770903 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature