Disentangling the effects of age and mild traumatic brain injury on brain network connectivity: A resting state fMRI study.

ABSTRACT:

Introduction

Cognitive complaints are common shortly after mild traumatic brain injury (mTBI) but may persist up to years. Age-related cognitive decline can worsen these symptoms. However, effects of age on mTBI sequelae have scarcely been investigated.

Methods

Fifty-four mTBI patients (median age: 35 years, range 19-64 years, 67% male) and twenty age- and sex-matched healthy controls were studied using resting state functional magnetic resonance imaging in the sub-acute phase. Independent component analysis was used to identify intrinsic connectivity networks (ICNs). A multivariate approach was adopted to evaluate the effects of age and group on the ICNs in terms of (static) functional network connectivity (FNC), intensities of spatial maps (SMs) and time-course spectral po

SUBMITTER: Bittencourt-Villalpando M 

PROVIDER: S-EPMC7770973 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature