The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men.

ABSTRACT:

Aim

To compare the effects of cold exposure and the β3-adrenergic receptor agonist mirabegron on plasma lipids, energy expenditure and brown adipose tissue (BAT) activity in South Asians versus Europids.

Materials and methods

Ten lean Dutch South Asian (aged 18-30 years; body mass index [BMI] 18-25 kg/m² ) and 10 age- and BMI-matched Europid men participated in a randomized, double-blinded, cross-over study consisting of three interventions: short-term (~ 2 hours) cold exposure, mirabegron (200 mg one dose p.o.) and placebo. Before and after each intervention, we performed lipidomic analysis in serum, assessed resting energy expenditure (REE) and skin temperature, and measured BAT fat fraction by magnetic resonance imaging.

Results

In both ethnicities, cold

SUBMITTER: Nahon KJ 

PROVIDER: S-EPMC7771034 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature