Network-based drug sensitivity prediction.

ABSTRACT:

Background

Drug sensitivity prediction and drug responsive biomarker selection on high-throughput genomic data is a critical step in drug discovery. Many computational methods have been developed to serve this purpose including several deep neural network models. However, the modular relations among genomic features have been largely ignored in these methods. To overcome this limitation, the role of the gene co-expression network on drug sensitivity prediction is investigated in this study.

Methods

In this paper, we first introduce a network-based method to identify representative features for drug response prediction by using the gene co-expression network. Then, two graph-based neural network models are proposed and both models integrate gene network information directly i

SUBMITTER: Ahmed KT 

PROVIDER: S-EPMC7771088 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature