Prognostic value and co-expression patterns of metabolic pathways in cancers.

ABSTRACT:

Background

Abnormal metabolic pathways have been considered as one of the hallmarks of cancer. While numerous metabolic pathways have been studied in various cancers, the direct link between metabolic pathway gene expression and cancer prognosis has not been established.

Results

Using two recently developed bioinformatics analysis methods, we evaluated the prognosis potential of metabolic pathway expression and tumor-vs-normal dysregulations for up to 29 metabolic pathways in 33 cancer types. Results show that increased metabolic gene expression within tumors corresponds to poor cancer prognosis. Meta differential co-expression analysis identified four metabolic pathways with significant global co-expression network disturbance between tumor and normal samples. Differential

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7771089 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature