IntePareto: an R package for integrative analyses of RNA-Seq and ChIP-Seq data.

ABSTRACT:

Background

RNA-Seq, the high-throughput sequencing (HT-Seq) of mRNAs, has become an essential tool for characterizing gene expression differences between different cell types and conditions. Gene expression is regulated by several mechanisms, including epigenetically by post-translational histone modifications which can be assessed by ChIP-Seq (Chromatin Immuno-Precipitation Sequencing). As more and more biological samples are analyzed by the combination of ChIP-Seq and RNA-Seq, the integrated analysis of the corresponding data sets becomes, theoretically, a unique option to study gene regulation. However, technically such analyses are still in their infancy.

Results

Here we introduce intePareto, a computational tool for the integrative analysis of RNA-Seq and ChIP-Seq data.

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7771091 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature