Semiquantitative Parameters in PSMA-Targeted PET Imaging with [¹⁸F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake.

ABSTRACT:

Purpose

In this study, we aimed to quantitatively investigate the biodistribution of [¹⁸F]DCFPyL in patients with prostate cancer (PCa) and to determine whether uptake in normal organs correlates with an increase in tumor burden.

Procedures

Fifty patients who had been imaged with [¹⁸F]DCFPyL positron emission tomography/computed tomography (PET/CT) were retrospectively included in this study. Forty of 50 (80 %) demonstrated radiotracer uptake on [¹⁸F]DCFPyL PET/CT compatible with sites of PCa. Volumes of interests (VOIs) were set on normal organs (lacrimal glands, parotid glands, submandibular glands, liver, spleen, and kidneys) and on tumor lesions. Mean standardized uptake values corrected to lean body mass (SUL_mean) and mean sta

SUBMITTER: Werner RA 

PROVIDER: S-EPMC7771227 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature