An Integrative Computational Approach for the Prediction of Human-Plasmodium Protein-Protein Interactions.

ABSTRACT: Host-pathogen molecular cross-talks are critical in determining the pathophysiology of a specific infection. Most of these cross-talks are mediated via protein-protein interactions between the host and the pathogen (HP-PPI). Thus, it is essential to know how some pathogens interact with their hosts to understand the mechanism of infections. Malaria is a life-threatening disease caused by an obligate intracellular parasite belonging to the Plasmodium genus, of which P. falciparum is the most prevalent. Several previous studies predicted human-plasmodium protein-protein interactions using computational methods have demonstrated their utility, accuracy, and efficiency to identify the interacting partners and therefore complementing experimental efforts to characterize host-patho

SUBMITTER: Ghedira K 

PROVIDER: S-EPMC7771252 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature