Canakinumab as treatment for COVID-19-related pneumonia: A prospective case-control study.

ABSTRACT:

Objectives

Canakinumab is an IL-1β antibody that neutralises the activity of IL-1β. This study examined the efficacy and safety of canakinumab in patients with moderate COVID-19-related pneumonia.

Design

This study aimed to evaluate the reduction in duration of hospitalisation with adequate oxygen status. Forty-eight patients with moderate COVID-19-related pneumonia were asked to participate in the prospective case-control study: 33 patients (cases) signed informed consent and received canakinumab (Cohort 1) and 15 patients (Controls) refused to receive the experimental drug and received institutional standard of care (Cohort 2).

Results

Hospital discharge within 21 days was seen in 63% of patients in Cohort 1 vs. 0% in Cohort 2 (median 14 vs. 26 days, respectively; p

SUBMITTER: Generali D 

PROVIDER: S-EPMC7771302 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature