The relationship between HPV status and chemoradiotherapy in the locoregional control of penile cancer.

ABSTRACT:

Background

Penile cancer (PeCa) is a rare, aggressive malignancy often associated with the human papillomavirus (HPV). The practice of a personalized risk-adapted approach is not yet established. This study is to assess the relationship between HPV tumor status and chemoradiotherapy (CRT) in PeCa locoregional control (LRC).

Methods

We retrospectively identified patients with HPV status who were diagnosed with squamous cell carcinoma of the penis and treated with surgical resection between 1999 and 2016. The relationship between tumor/treatment characteristics and LRC were analyzed with univariate and multivariate Cox proportional hazard regression analysis (UVA and MVA, respectively). Time-to-event outcomes were estimated with Kaplan-Meier curves and compared via log-rank te

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC7771321 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature