Alterations in genetic pathways following radiotherapy for head and neck cancer.

ABSTRACT:

Background

Radiotherapy (RT) is an integral component in the treatment of head and neck cancer (HNC).We hypothesized there would be alterations in gene-expression and pathway activity in HNC samples obtained in recurrent HNC that were previously treated with RT, when compared to RT-naïve disease.

Methods

Patient data was abstracted from a prospectively maintained database. Linear-microarray analysis and supervised gene-set enrichment-analysis were employed to compare RT-naive and recurrent disease after prior-RT.

Results

A total of 157 patients were analyzed, 96 (61%) were RT-naive and 61 (39%) had RT.After radiation, there was upregulation of genes associated with angiogenesis, protein-translation-machinery, cell-cycle regulation, and growth factors, and downregulati

SUBMITTER: Naghavi AO 

PROVIDER: S-EPMC7771332 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature