Radiosensitivity index predicts for survival with adjuvant radiation in resectable pancreatic cancer.

ABSTRACT:

Background and purpose

Adjuvant radiation therapy for resectable pancreatic cancer remains controversial. Sub-populations of radiosensitive tumors might exist given the genetic heterogeneity of pancreatic cancers. We evaluated whether RSI is predictive of survival in pancreatic cancer treated with radiation.

Materials and methods

We identified 73 genomically-profiled pancreas cancer patients treated with upfront surgery between 2000 and 2011 (48 radiation, 25 no radiation). Briefly, RSI score is derived from the expression of 10 specific genes and a linear regression algorithm modeled on SF2 of 48 cancer cells. The primary endpoint was to assess the association of RSI with overall survival.

Results

Median follow-up was 67months for surviving patients. On multivariate

SUBMITTER: Strom T 

PROVIDER: S-EPMC7771365 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature