Identification and classification of interstitial cells in the mouse renal pelvis.

ABSTRACT:

Key points

Platelet-derived growth factor receptor-α (PDGFRα) is a novel biomarker along with smooth myosin heavy chain for the pacemaker cells (previously termed 'atypical' smooth muscle cells) in the murine and cynomolgus monkey pelvis-kidney junction. PDGFRα⁺ cells present in adventitial and urothelial layers of murine renal pelvis do not express smooth muscle myosin heavy chain (smMHC) but are in close apposition to nerve fibres. Most c-Kit⁺ cells in the renal pelvis are mast cells. Mast cells (CD117⁺ /CD45⁺ ) are more abundant in the proximal renal pelvis and pelvis-kidney junction regions whereas c-Kit⁺ interstitial cells (CD117⁺ /CD45^- ) are found predominantly in the distal renal pelvis and uretero

SUBMITTER: Grainger N 

PROVIDER: S-EPMC7771379 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature