Prevalence of Germline Pathogenic and Likely Pathogenic Variants in Patients With Second Breast Cancers.

ABSTRACT:

Background

Few studies have examined gene-specific associations with contralateral and/or second breast cancer (SBC).

Methods

The frequency of pathogenic and likely pathogenic (P/LP) variants in clinically actionable genes (BRCA1, BRCA2, PTEN, TP53, CHEK2, CDH1, ATM, PALB2, NBN, and NF1) was compared between women with a primary breast cancer (PBC) and SBC who underwent multigene panel testing at a single diagnostic testing laboratory. Race- and ethnicity-specific logistic regression burden tests adjusted for age at diagnosis of first breast cancer, histology, presence of first- or second-degree relatives with breast cancer, and prior testing for BRCA1/2 genes were used to test for associations with

SUBMITTER: Yao K KA 

PROVIDER: S-EPMC7771422 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature