Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45.

ABSTRACT: Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo-assembled genomes were used to understand genomic plasticity and to perform coalescent analyses. The ST45 population contained two distinct sublineages, which correlated with the isolates' geographical origins. One sublineage primarily consisted of European/North American isolates, while the second sublineage primarily consisted of African and Australi

SUBMITTER: Effelsberg N 

PROVIDER: S-EPMC7771469 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature