Metabolic functions of the human gut microbiota: the role of metalloenzymes.

ABSTRACT: Covering: up to the end of 2017 The human body is composed of an equal number of human and microbial cells. While the microbial community inhabiting the human gastrointestinal tract plays an essential role in host health, these organisms have also been connected to various diseases. Yet, the gut microbial functions that modulate host biology are not well established. In this review, we describe metabolic functions of the human gut microbiota that involve metalloenzymes. These activities enable gut microbial colonization, mediate interactions with the host, and impact human health and disease. We highlight cases in which enzyme characterization has advanced our understanding of the gut microbiota and examples that illustrate the diverse ways in which metalloenzymes facilitate both essential

SUBMITTER: Rajakovich LJ 

PROVIDER: S-EPMC7771511 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature