Genotyping Squamous Cell Lung Carcinoma in Colombia (Geno1.1-CLICaP).

ABSTRACT:

Background

Lung cancer is a public health problem, and squamous cell carcinoma (SCC) is the second most prevalent subtype of this neoplasm. Compared to other subtypes, including adenocarcinoma, SCC is less well understood in terms of molecular pathogenesis, limiting therapeutic options among targeted agents approved for other disease subgroups. In this study, we sought to characterize the SCC genomic profile using a validated Next Generation Sequencing (NGS) platform.

Methods

The comprehensive NGS assay (TruSight Tumor 170) was used in order to target the full coding regions of 170 cancer-related genes on SCC samples. PD-L1 expression in tumor cells (TCs) was assessed using clone 22C3 (Dako). Clinical outcomes were correlated with molecular profile, including progress

SUBMITTER: Cardona AF 

PROVIDER: S-EPMC7771515 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature