A Phase II Study of Ibrutinib in Advanced Neuroendocrine Neoplasms.

ABSTRACT:

Background

Ibrutinib is an orally administered inhibitor of Bruton's tyrosine kinase (Btk). Preclinical data suggest that mast cells are recruited within neuroendocrine neoplasms (NENs) where they stimulate angiogenesis and tumor growth. Ibrutinib inhibits mast cell degranulation and has been associated with regression of tumors in a mouse insulinoma model.

Methods

A prospective, phase II trial evaluated patients with advanced gastrointestinal (GI)/lung NENs and pancreatic NENs (pNENs) who had evidence of progression within 12 months of study entry on at least one prior therapy. Patients received ibrutinib 560 mg daily until unacceptable toxicity, progression of disease, or withdrawal of consent. The primary endpoint was objective response rate.

Results

Twenty patient

SUBMITTER: Al-Toubah T 

PROVIDER: S-EPMC7771542 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature