Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis.

ABSTRACT: Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteoblast differentiation program. To gain insights into this process we profiled the effects of co-culture of primary MSCs with validated bone metastatic prostate cancer cell line models. These analyses revealed a cast of shared differentially induced genes in MSC, including betaglycan, a co-receptor for TGFβ. Betaglycan has not been studied in the context of bone metastatic disease previously. Here we report that loss of betaglycan in MSC is sufficient to augment TGFβ signaling,

SUBMITTER: Cook LM 

PROVIDER: S-EPMC7771554 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature