Perioperative changes of response to antiplatelet medication in vascular surgery patients.

ABSTRACT:

Introduction

Reduced antiplatelet activity of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events. The reported prevalence data for low-responders vary widely and there have been few investigations in vascular surgery patients even though they are at high risk for thromb-embolic complications. The aim of this prospective observational monocentric study was to elucidate possible changes in ALR or CLR after common vascular procedures.

Methods

Activity of aspirin and clopidogrel was measured by impedance aggregometry using a multiple electrode aggregometer (Multiplate®). Possible risk factors for ALR or CLR were identified by demographical, clinical data and laboratory parameters. In addition, a follow-up aggregometry was performed a

SUBMITTER: Hummel T 

PROVIDER: S-EPMC7771706 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature