Identification and Verification of Immune-Related Gene Prognostic Signature Based on ssGSEA for Osteosarcoma.

ABSTRACT: Osteosarcoma is the most common malignant bone tumor in children and adolescence. Multiple immune-related genes have been reported in different cancers. The aim is to identify an immune-related gene signature for the prospective evaluation of prognosis for osteosarcoma patients. In this study, we evaluated the infiltration of immune cells in 101 osteosarcoma patients downloaded from TARGET using the ssGSEA to the RNA-sequencing of these patients, thus, high immune cell infiltration cluster, middle immune cell infiltration cluster and low immune cell infiltration cluster were generated. On the foundation of high immune cell infiltration cluster vs. low immune cell infiltration cluster and normal vs. osteosarcoma, we found 108 common differentially expressed genes which were sequentially sub

SUBMITTER: Xiao B 

PROVIDER: S-EPMC7771722 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature