Metabolomic profiles associated with subtypes of prediabetes among Mexican Americans in Starr County, Texas, USA.

ABSTRACT:

Aims/hypothesis

To understand the complex metabolic changes that occur long before the diagnosis of type 2 diabetes, we investigated differences in metabolomic profiles in plasma between prediabetic and normoglycaemic individuals for subtypes of prediabetes defined by fasting glucose, 2 h glucose and HbA_1c measures.

Methods

Untargeted metabolomics data were obtained from 155 plasma samples from 127 Mexican American individuals from Starr County, TX, USA. None had type 2 diabetes at the time of sample collection and 69 had prediabetes by at least one criterion. We tested statistical associations of amino acids and other metabolites with each subtype of prediabetes.

Results

We identified distinctive differences in amino acid profiles between prediabetic and n

SUBMITTER: Jun G 

PROVIDER: S-EPMC7771728 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature