Impact of deep brain stimulation of the subthalamic nucleus on natural language in patients with Parkinson's disease.

ABSTRACT:

Background

In addition to the typical motor symptoms, a majority of patients suffering from Parkinson's disease experience language impairments. Deep Brain Stimulation of the subthalamic nucleus robustly reduces motor dysfunction, but its impact on language skills remains ambiguous.

Method

To elucidate the impact of subthalamic deep brain stimulation on natural language production, we systematically analyzed language samples from fourteen individuals (three female / eleven male, average age 66.43 ± 7.53 years) with Parkinson's disease in the active (ON) versus inactive (OFF) stimulation condition. Significant ON-OFF differences were considered as stimulation effects. To localize their neuroanatomical origin within the subthalamic nucleus, they were correlated with the volume

SUBMITTER: Ehlen F 

PROVIDER: S-EPMC7771859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature