The TP63 Gene Polymorphism rs17506395 is Associated with Early Breast Cancer in Cameroon.

ABSTRACT:

Background

Breast cancer (BC) is a leading female cancer worldwide and cause of cancer-related death, especially in developing countries. Genetic predispositions to BC development in African population is poorly studied, and meanwhile the SNP rs17506395 in TP63 gene locus has been associated with the development of breast cancer in Asian women, no investigation has been undertaken within African population. We investigated the impact of this polymorphism in a representative African population.

Methods

We undertook a case-control study including 335 women, of which 111 were breast cancer patients and 224 controls. Using blood-derived germline DNA, PCR-RFLP was used to investigate the polymorphism of TP63 gene at rs17506395 locus. Unconditional logistic regression was used to

SUBMITTER: Tiofack ATZ 

PROVIDER: S-EPMC7771916 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature