The Large Scale Structure of Human Metabolism Reveals Resilience via Extensive Signaling Crosstalk.

ABSTRACT: Metabolism is loosely defined as the set of physical and chemical interactions associated with the processes responsible for sustaining life. Two evident features arise whenever one looks at metabolism: first, metabolism is conformed as a very complex and intertwined construct of the many associated biomolecular processes. Second, metabolism is characterized by a high degree of stability reflected by the organisms resilience to either environmental changes or pathogenic conditions. Here we will investigate the relationship between these two features. By having access to the full set of human metabolic interactions as reported in the highly curated KEGG database, we built an integrated human metabolic network comprising metabolic, transcriptional regulation, and protein-protein interaction

SUBMITTER: Gomez-Romero L 

PROVIDER: S-EPMC7772240 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature