A systematic review of gene-by-intervention studies of alcohol and other substance use.

ABSTRACT: Alcohol and other substance use problems are common, and the efficacy of current prevention and intervention programs is limited. Genetics may contribute to differential effectiveness of psychosocial prevention and intervention programs. This paper reviews gene-by-intervention (G×I) studies of alcohol and other substance use, and implications for integrating genetics into prevention science. Systematic review yielded 17 studies for inclusion. Most studies focused on youth substance prevention, alcohol was the most common outcome, and measures of genotype were heterogeneous. All studies reported at least one significant G×I interaction. We discuss these findings in the context of the history and current state of genetics, and provide recommendations for future G×I research. These include th

SUBMITTER: Neale ZE 

PROVIDER: S-EPMC7772257 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature