Unique skin abnormality in patients with peanut allergy but no atopic dermatitis.

ABSTRACT:

Background

The nonlesional skin of children with atopic dermatitis (AD) with peanut allergy (PA) is associated with increased transepidermal water loss; low urocanic acid (UCA) and pyrrolidone carboxylic acid (PCA), both of which are filaggrin breakdown products; and a reduced ratio of esterified ω-hydroxy fatty acid sphingosine ceramides (EOS-CERs) to nonhydroxy fatty acid sphingosine ceramides (NS-CERs) in the skin. The skin barrier of subjects with PA without AD (AD^-PA⁺) has not been studied.

Objective

Our aim was to explore whether AD^-PA⁺ is associated with skin barrier abnormalities.

Methods

A total of 33 participants were enrolled, including 13 AD^-PA⁺, 9 AD⁺PA⁺, and 11 nonato

SUBMITTER: Berdyshev E 

PROVIDER: S-EPMC7772264 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature