Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology.

ABSTRACT:

Objective

Neuroimaging research has revealed that structural brain alterations are common across broad diagnostic families of disorders rather than specific to a single psychiatric disorder. Such overlap in the structural brain correlates of mental disorders mirrors already well-documented phenotypic comorbidity of psychiatric symptoms and diagnoses, which can be indexed by a general psychopathology or p factor. The authors hypothesized that if general psychopathology drives the convergence of structural alterations common across disorders, then 1) there should be few associations unique to any one diagnostic family of disorders, and 2) associations with the p factor should overlap with those for the broader diagnostic families.

Methods

Analyses were conducted

SUBMITTER: Romer AL 

PROVIDER: S-EPMC7772268 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature