Dose-response association between fluid overload and in-hospital mortality in critically ill patients: a multicentre, prospective, observational cohort study.

ABSTRACT:

Objectives

Fluid management is important in ensuring haemodynamic stability in critically ill patients, but can easily lead to fluid overload (FO). However, the optimal fluid balance plot or range for critically ill patients is unknown. This study aimed to explore the dose-response relationship between FO and in-hospital mortality in critically ill patients.

Design

Multicentre, prospective, observational study.

Setting

Eighteen intensive care units (ICUs) of 16 tertiary hospitals in China.

Participants

Critically ill patients in the ICU for more than 3 days.

Primary outcome measures and analyses

FO was defined as the ratio of the cumulative fluid balance (L) and initial body weight (kg) on ICU admission, expressed as a percentage. Maximum FO was defined

SUBMITTER: Wang M 

PROVIDER: S-EPMC7772328 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature