Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach.

ABSTRACT: During the mammalian preimplantation phase, cells undergo two subsequent cell fate decisions. During the first decision, the trophectoderm and the inner cell mass are formed. Subsequently, the inner cell mass segregates into the epiblast and the primitive endoderm. Inner cell mass organoids represent an experimental model system, mimicking the second cell fate decision. It has been shown that cells of the same fate tend to cluster stronger than expected for random cell fate decisions. Three major processes are hypothesised to contribute to the cell fate arrangements: (1) chemical signalling; (2) cell sorting; and (3) cell proliferation. In order to quantify the influence of cell proliferation on the observed cell lineage type clustering, we developed an agent-based model accounting for mec

SUBMITTER: Liebisch T 

PROVIDER: S-EPMC7772343 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature