Testosterone metabolites differentially regulate obesogenesis and fat distribution.

ABSTRACT:

Objective

Low testosterone in men (hypogonadism) is associated with obesity and type II diabetes. Testosterone replacement therapy has been shown to reverse these effects. However, the mechanisms by which testosterone regulates total fat mass, fat distribution, and metabolic health are unclear. In this study, we clarify the impact of hypogonadism on these parameters, as well as parse the role of testosterone from its downstream metabolites, dihydrotestosterone (DHT), and estradiol, in the regulation of depot-specific adipose tissue mass.

Methods

To achieve this objective, we utilized mouse models of male hypogonadism coupled with hormone replacement therapy, magnetic resonance imaging (MRI), glucose tolerance tests, flow cytometry, and immunohistochemical techniques.

Resu

SUBMITTER: Sebo ZL 

PROVIDER: S-EPMC7772371 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature