Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans.

ABSTRACT: The brain requires a large amount of energy, mostly derived from the metabolism of glucose, which decreases substantially with age and neurological diseases. While mounting evidence in model organisms illustrates the central role of brain nicotinamide adenine dinucleotide (NAD) for maintaining energy homeostasis, similar data are sparse in humans. This study explores the correlations between brain NAD, energy production and membrane phospholipid metabolism by 31-phosphorous magnetic resonance spectroscopy (³¹P-MRS) across 50 healthy participants including a young (mean age 27.1-year-old) and middle-aged (mean age 56.4-year-old) group. The analysis revealed that brain NAD level and NAD⁺/NADH redox ratio were positively associated with ATP level and the rate of energy p

SUBMITTER: Cuenoud B 

PROVIDER: S-EPMC7772416 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature