Effect of seeds of Entada phaseoloides on chronic restrain stress in mice.

ABSTRACT:

Background

Entada phaseoloides is a well-known medicinal plant traditionally used in Ayurvedic medicine for centuries.

Objective

To evaluate the anti-stress activity of seeds of E. phaseoloides in endoplasmic reticulum stress during chronic restrain stress in mice, based on our preliminary screening.

Materials and methods

Mice (n = 6/group) were restrained daily for 6 h in 50 ml polystyrene tubes for 28 days. Methanolic extract of E. phaseoloides (MEEP) (100 and 200 mg/kg, p.o.) and standard drug, imipramine (10 mg/kg i.p.) were administered daily 45 min prior to restrain from day 22-28. Then, forced swim test (FST) was performed to assess despair behavior. Lipid peroxidation (LPO) and antioxidant enzymes Reduced glutathione (GSH), Superoxide dismutase (SOD) were meas

SUBMITTER: Barua CC 

PROVIDER: S-EPMC7772487 | biostudies-literature | 2020 Oct-Dec

REPOSITORIES: biostudies-literature