Polyoxygenated seco-cyclohexenes derivatives from flower and leaf extracts of Desmos cochinchinensis and their α-glucosidase inhibitory activity.

ABSTRACT: Phytochemical investigations from the flower and leaf extracts of D. cochinchinensis resulted in the isolation and structural elucidation of five new polyoxygenated seco-cyclohexene derivatives, desmoscochinchinenes A-E (1-5), together with 11 known compounds (6-16). The structures on the new compounds were elucidated from their spectroscopic data, including UV, IR, NMR, and HRESITOFMS. Some of the isolated compounds were evaluated for their α-glucosidase inhibitory activities. Chrysin (9), pinocembrin 7-O-benzoate (12), and (-)-(5R)-desmoscochinoxepinone B (16) inhibited α-glucosidase better than the standard control (acarbose, IC₅₀ = 83.5 μM) with IC₅₀ values of 5.7, 33.8, 53.

SUBMITTER: Suthiphasilp V 

PROVIDER: S-EPMC7772550 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature