Association of Gabapentinoids With the Risk of Opioid-Related Adverse Events in Surgical Patients in the United States.

ABSTRACT:

Importance

The use of gabapentinoids in multimodal postoperative analgesia is increasing; however, when coadministered with opioids, these drugs may potentiate central nervous system and respiratory depression.

Objective

To evaluate the association between perioperative coadministration of gabapentinoids and opioids with inpatient opioid-related adverse events in surgical patients.

Design, setting, and participants

This cohort study used propensity score trimming, stratification, and weighting of adults admitted for a major surgery between October 2007 and December 2017 who were treated with opioids on the day of surgery and included in the Premier Research database. Data analysis was conducted from February to April 2020.

Exposure

Gabapentinoids (gabapentin or

SUBMITTER: Bykov K 

PROVIDER: S-EPMC7772715 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature