Validation of genetic variants associated with metabolic dysfunction-associated fatty liver disease in an ethnic Chinese population.

ABSTRACT:

Background

Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease (MAFLD).

Aim

To study the association of single nucleotide polymorphisms (SNPs), previously identified in Western populations, with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk factors.

Methods

A retrospective case-control study was conducted with 72 MAFLD cases and 72 controls with no hepatic steatosis on computed tomography, magnetic resonance imaging, or controlled attenuation parameter score. Subjects were recruited from two tertiary hospitals. Genetic alleles such as NCAN, GCKR, LYPLAL1, PNPLA3, PPP1R3B, FDFT1, COL

SUBMITTER: Lee GH 

PROVIDER: S-EPMC7772735 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature