Monitoring Eosinophilic Esophagitis Disease Activity With Blood Eosinophil Progenitor Levels.

ABSTRACT:

Objectives

A minimally invasive biomarker to monitor disease activity is one of the greatest unmet clinical needs of the pediatric eosinophilic esophagitis (EoE) population. We aimed to determine whether circulating eosinophil progenitors (EoPs) could be used as a biomarker to identify pediatric patients with active EoE.

Methods

In a prospective observational study, peripheral blood samples, symptom history, and laboratory data were collected from pediatric patients undergoing endoscopy for evaluation of EoE on dietary therapy at Cincinnati Children's Hospital. Peripheral blood EoP level was determined by flow cytometry.

Results

Thirty-four children with active (n = 16) and inactive (n = 18) EoE were included in the analysis. EoP levels in the peripheral blood were 3-

SUBMITTER: Henderson A 

PROVIDER: S-EPMC7772866 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature