LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project

ABSTRACT: Abstract

INTRODUCTION

We examined associations between nutritional biomarkers and clinical progression in individuals with subjective cognitive decline (SCD), mild cognitive impairment (MCI), and Alzheimer's disease (AD)‐type dementia.

METHODS

We included 528 individuals (64 ± 8 years, 46% F, follow‐up 2.1 ± 0.87 years) with SCD (n = 204), MCI (n = 130), and AD (n = 194). Baseline levels of cholesterol, triglycerides, glucose, homocysteine, folate, vitamin A, B12, E and uridine were measured in blood and S‐adenosylmethionine and S‐adenosylhomocysteine in cerebrospinal fluid. We determined associations between nutritional biomarkers and clinical progression using Cox proportional hazard models.

RESULTS

Twenty‐two (11%) patients with SCD, 45 (35%) patients with MCI

SUBMITTER: de Leeuw F 

PROVIDER: S-EPMC7772937 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature