Ontology highlight
ABSTRACT:
SUBMITTER: Wiedemann GM
PROVIDER: S-EPMC7773031 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wiedemann Gabriela M GM Grassmann Simon S Lau Colleen M CM Rapp Moritz M Villarino Alejandro V AV Friedrich Christin C Gasteiger Georg G O'Shea John J JJ Sun Joseph C JC
Cell reports 20201201 11
Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the roles of this transcription factor and its upstream cytokines interleukin-2 (IL-2) and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. We dem ...[more]