Next-generation regulatory T cell therapy.

ABSTRACT: Regulatory T cells (T_reg cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune homeostasis. Accordingly, deficiencies in T_reg cell development or function result in uncontrolled immune responses and tissue destruction and can lead to inflammatory disorders such as graft-versus-host disease, transplant rejection and autoimmune diseases. As T_reg cells deploy more than a dozen molecular mechanisms to suppress immune responses, they have potential as multifaceted adaptable smart therapeutics for treating inflammatory disorders. Indeed, early-phase clinical trials of T_reg cell therapy have shown feasibility, tolerability and potential efficacy in these disease settings. In the meanti

SUBMITTER: Ferreira LMR 

PROVIDER: S-EPMC7773144 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature