Throughput-Speed Product Augmentation for Scanning Fiber-Optic Two-Photon Endomicroscopy.

ABSTRACT: Compactness, among several others, is one unique and very attractive feature of a scanning fiber-optic two-photon endomicroscope. To increase the scanning area and the total number of resolvable pixels (i.e., the imaging throughput), it typically requires a longer cantilever which, however, leads to a much undesired, reduced scanning speed (and thus imaging frame rate). Herein we introduce a new design strategy for a fiber-optic scanning endomicroscope, where the overall numerical aperture (NA) or beam focusing power is distributed over two stages: 1) a mode-field focuser engineered at the tip of a double-clad fiber (DCF) cantilever to pre-amplify the single-mode core NA, and 2) a micro objective of a lower magnification (i.e.,  ∼ 2× in this design) to achieve final tight beam focusing. Th

SUBMITTER: Liang W 

PROVIDER: S-EPMC7773217 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature