IP-10 and CXCR3 signaling inhibit Zika virus replication in human prostate cells.

ABSTRACT: Our previous studies have shown that Zika virus (ZIKV) replicates in human prostate cells, suggesting that the prostate may serve as a long-term reservoir for virus transmission. Here, we demonstrated that the innate immune responses generated to three distinct ZIKV strains (all isolated from human serum) were significantly different and dependent on their passage history (in mosquito, monkey, or human cells). In addition, some of these phenotypic differences were reduced by a single additional cell culture passage, suggesting that viruses that have been passaged more than 3 times from the patient sample will no longer reflect natural phenotypes. Two of the ZIKV strains analyzed induced high levels of the IP-10 chemokine and IFNγ in human prostate epithelial and stromal mesenchymal stem ce

SUBMITTER: Spencer Clinton JL 

PROVIDER: S-EPMC7773246 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature