Assessing the low complexity of protein sequences via the low complexity triangle.

ABSTRACT:

Background

Proteins with low complexity regions (LCRs) have atypical sequence and structural features. Their amino acid composition varies from the expected, determined proteome-wise, and they do not follow the rules of structural folding that prevail in globular regions. One way to characterize these regions is by assessing the repeatability of a sequence, that is, calculating the local propensity of a region to be part of a repeat.

Results

We combine two local measures of low complexity, repeatability (using the RES algorithm) and fraction of the most frequent amino acid, to evaluate different proteomes, datasets of protein regions with specific features, and individual cases of proteins with extreme compositions. We apply a representation called 'low complexity triangle'

SUBMITTER: Mier P 

PROVIDER: S-EPMC7773278 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature