Intrathecal catheter implantation decreases cerebrospinal fluid dynamics in cynomolgus monkeys.

ABSTRACT: A detailed understanding of the CSF dynamics is needed for design and optimization of intrathecal drug delivery devices, drugs, and protocols. Preclinical research using large-animal models is important to help define drug pharmacokinetics-pharmacodynamics and safety. In this study, we investigated the impact of catheter implantation in the sub-dural space on CSF flow dynamics in Cynomolgus monkeys. Magnetic resonance imaging (MRI) was performed before and after catheter implantation to quantify the differences based on catheter placement location in the cervical compared to the lumbar spine. Several geometric and hydrodynamic parameters were calculated based on the 3D segmentation and flow analysis. Hagen-Poiseuille equation was used to investigate the impact of catheter implantation on f

SUBMITTER: Khani M 

PROVIDER: S-EPMC7773283 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature